Archive - Letters from a Zeneca

Letter 109: All About Local LLMs

The complete guide to running AI models on your own computer

Apr 21

Letter 108: What Are LLMs, and How Do They Work?

You've been using them every day. Here's what's going on under the hood.

Apr 14

Letter 107: Setting Up an AI Agent

Claude vs Hermes: which is better for you, and how to get started?

Apr 7

March 2026

Letter 106: The Token Graveyard

Inside the numbers that explain why nearly everything in crypto goes to zero

Mar 30

Letter 105: Reader Portfolio Review

Going through a reader's crypto portfolio, token by token

Mar 24

Letter 104: Using Domain Knowledge for your Prediction Model

A prediction model is a tool anyone can create, domain knowledge is what makes it excel

Mar 17

Weekly Nugget of Wisdom #46

Dealing with AI Anxiety and FOMO

Mar 12

Letter 103: How to Vibe Code a Prediction Model

A step-by-step guide to building a prediction model with AI, no machine learning background required

Mar 10

Letter 102: Looking at the Venice AI ecosystem

Including a break down of how their VVV and DIEM tokens work

Mar 2 • Zeneca

February 2026

Little Learnings #7

What Are AI Agents, Actually?

Feb 27 • Zeneca

Weekly Nugget of Wisdom #45

Think about your information diet

Feb 26

Letter 101: What does my portfolio look like in 2026?

This time I also include assets outside of crypto: real estate, stocks, etc

Feb 24 • Zeneca

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